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ChIP-on-chip, also known as genome-wide location analysis, is a technique for isolation and identification of the DNA sequences occupied by specific DNA binding proteins in cells. These binding sites may indicate functions of various transcriptional regulators and help identify their target genes during animal development and disease progression. The identified binding sites may also be used as a basis for annotating functional elements in genomes. The types of functional elements that one can identify using ChIP-on-chip include promoters, enhancers, repressor and silencing elements, insulators, boundary elements, and sequences that control DNA replication. The ChIP-on-chip is a technological platform used by the ENCODE consortium to map functional elements in the human genome. Please click on the picture above to find information on ChIP-on-chip literature, protocols, ChIP-grade antibodies, data analysis software, and commercial DNA microarrays suitable for ChIP-on-chip.
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